{"id":3460,"date":"2026-08-05T12:00:00","date_gmt":"2026-08-05T12:00:00","guid":{"rendered":"https:\/\/cicds.umfcd.ro\/?post_type=lucrari_cercetari&p=3460"},"modified":"2026-08-15T00:03:09","modified_gmt":"2026-08-15T00:03:09","slug":"dental-luting-cements-and-peri-implantitis-molecular-mechanisms-clinical-implications-and-the-role-of-autophagy-and-nanotechnologya-narrative-review","status":"publish","type":"lucrari_cercetari","link":"https:\/\/cicds.umfcd.ro\/en\/lucrari_cercetari\/dental-luting-cements-and-peri-implantitis-molecular-mechanisms-clinical-implications-and-the-role-of-autophagy-and-nanotechnologya-narrative-review\/","title":{"rendered":"Dental Luting Cements and Peri-Implantitis: Molecular Mechanisms, Clinical Implications and the Role of Autophagy and Nanotechnology\u2014A Narrative Review"},"content":{"rendered":"
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Dental Luting Cements and Peri-Implantitis: Molecular Mechanisms, Clinical Implications and the Role of Autophagy and Nanotechnology\u2014A Narrative Review<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\tBucat\u0103, A.; Ciocan, L.T.; Ripszky, A.; T\u0103nase, M.; Radu, R.; Izet, M.; Cernega, A.; Imre, M.M.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tDentistry Journal<\/em> 2026, 14, 485.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\tAbstract\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tBackground and Objectives: This narrative review aims to evaluate the correlation between dental luting cements, peri-implantitis and the molecular mechanisms governing tissue destruction, with a specific focus on the role of autophagy and nanotechnology. Methods: A comprehensive literature search was conducted across electronic databases, including PubMed, Scopus and Web of Science, to identify relevant studies on cement cytotoxicity, cellular responses and nanomaterial integration. Results: Residual cement in the peri-implant sulcus promotes biofilm accumulation and severe inflammation. At a cellular level, resin-base monomers (e.g., Bis-GMA) impair human gingival fibroblasts via oxidative stress and mitochondrial dysfunction. Autophagy serves as a vital cytoprotective mechanism against cement toxicity and titanium particle accumulation. Experimental studies suggest that incorporating nanomaterials, specifically graphene oxide and silver nanoparticles (\u22641 wt.%), has shown promising results in enhancing antimicrobial efficacy without compromising biocompatibility in vitro. Conclusions: To minimize peri-implantitis, clinical protocols should prioritize the meticulous removal of excess cement and the development of nano-reinforced luting agents. Optimizing these molecular pathways offers actionable preventive strategies, guiding clinicians toward safer cementation protocols and enhanced long-term implant success.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Keywords: <\/strong><\/p>

cemented crown vs. screw-retained crowns; dental luting cement; peri-implantitis; autophagy; nanotechnology; nanomaterials<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tRead the paper online<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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