{"id":3432,"date":"2026-04-07T12:00:00","date_gmt":"2026-04-07T12:00:00","guid":{"rendered":"https:\/\/cicds.umfcd.ro\/?post_type=lucrari_cercetari&p=3432"},"modified":"2026-08-15T00:01:23","modified_gmt":"2026-08-15T00:01:23","slug":"differential-effects-of-curcumin-and-cordycepin-on-oral-squamous-cell-carcinoma-cells-ros-mediated-cytotoxicity-and-real-time-morphological-analysis","status":"publish","type":"lucrari_cercetari","link":"https:\/\/cicds.umfcd.ro\/en\/lucrari_cercetari\/differential-effects-of-curcumin-and-cordycepin-on-oral-squamous-cell-carcinoma-cells-ros-mediated-cytotoxicity-and-real-time-morphological-analysis\/","title":{"rendered":"Differential Effects of Curcumin and Cordycepin on Oral Squamous Cell Carcinoma Cells: ROS-Mediated Cytotoxicity and Real-Time Morphological Analysis"},"content":{"rendered":"
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Differential Effects of Curcumin and Cordycepin on Oral Squamous Cell Carcinoma Cells: ROS-Mediated Cytotoxicity and Real-Time Morphological Analysis<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\tVoicu Balasea, B.; Stan, M.S.; Radulescu, R.; Cernega, A.; Alm, K.; Musteanu, M.; Rus, F.; Ripszky, A.; Pituru, S.M.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tMolecules<\/em> 2026, 31, 1221.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\tAbstract\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tOral squamous cell carcinoma (OSCC) remains a major clinical challenge, highlighting the need for novel therapeutic strategies. Natural bioactive compounds such as curcumin (Cu) and cordycepin (Co) have shown anticancer potential; however, their effects on cancer cell morphology and behavior remain incompletely characterized. This study assessed the individual and combined effects of Cu and Co on oral squamous cell carcinoma cells (OECM-1) and normal human gingival epithelial cells (HGEpiC) over 24 and 48 h. Metabolic activity, membrane integrity, oxidative stress, apoptosis, and inflammatory responses were evaluated using MTT, LDH, ROS-H2O2, caspase 3\/7, and NO assays. Label-free digital holographic microscopy enabled real-time monitoring of morphology, motility, and proliferation. Both compounds induced ROS-mediated cytotoxicity, but responses were notably more pronounced in OECM-1 than in HGEpiC cells. Real-time morphological profiling revealed distinct response patterns: Co primarily exerted cytostatic effects, whereas Cu induced cell shrinkage, impaired motility, and inhibited cell division. The combination treatment (CC) largely reflected Cu-driven morphological and functional changes, with Co coexisting without counteracting Cu\u2019s effects. Taken together, these findings reveal compound-specific mechanisms of action for Cu and Co in OSCC therapy.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Keywords: <\/strong><\/p>

curcumin; cordycepin; oral squamous cell carcinoma; gingival epithelial cells; ROS; apoptosis; morphology<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tRead the paper online<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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