{"id":3113,"date":"2026-05-09T12:00:00","date_gmt":"2026-05-09T12:00:00","guid":{"rendered":"https:\/\/cicds.umfcd.ro\/?post_type=lucrari_cercetari&p=3113"},"modified":"2026-08-05T15:48:13","modified_gmt":"2026-08-05T15:48:13","slug":"dental-glass-ionomer-cement-for-root-perforation-management-physicochemical-characteristics-and-in-vitro-cell-response","status":"publish","type":"lucrari_cercetari","link":"https:\/\/cicds.umfcd.ro\/en\/lucrari_cercetari\/dental-glass-ionomer-cement-for-root-perforation-management-physicochemical-characteristics-and-in-vitro-cell-response\/","title":{"rendered":"Dental Glass Ionomer Cement for Root Perforation Management: Physicochemical Characteristics and In Vitro Cell Response"},"content":{"rendered":"
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Dental Glass Ionomer Cement for Root Perforation Management: Physicochemical Characteristics and In Vitro Cell Response<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Popa, A.; Radulescu, R.-V.; Rus, F.; Vasilescu, V.G.; Ciocan, L.T.; Musteanu, M.; Imre, M.; Pituru, S.; Cernega, A.; Ripszky, A.; Andronescu, E.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dentistry Journal 2026, 14, 284.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\tAbstract\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Background\/Objectives:<\/b> Root perforation treatment is essential for restoring the tightness of the root system, preventing periradicular inflammation and tooth loss. The present study aimed to evaluate the biocompatibility of Ketac\u2122 Molar EasyMix as well as conduct a thorough morphological and structural characterization of the material, considering its potential use in managing root perforations. Methods:<\/b> Morpho-structural characterization was performed by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT\u2013IR), and X-ray diffraction (XRD). Biocompatibility tests were performed on osteosarcoma cell line (ATCC\u2014G 292 CRL-1423), monitoring metabolic activity and cell viability (MTT, n<\/span> = 3), as well as the inflammatory response (nitric oxide\u2014NO, n<\/span> = 6), after 24 and 48 h of incubation. The control group consisted of cells unexposed to the material. Results:<\/b> Microstructurally, the material exhibits a heterogeneous structure, along with pores and cracks. The specific bonds of the material, including both organic acid (COO\u2212<\/sup>, O-H) and the glass components (Si-O-Al, Ca-O, C-F), were identified by FT-IR, while the crystalline phase composed of calcium fluorolanthanate was determined by XRD. Moreover, in vitro metabolic activity and viability test (MTT) showed a decrease of ~28% (p<\/span> = 0.029) and ~30% (p<\/span> = 0.150) after 24 and 48 h for samples incubated with Ketac\u2122 Molar EasyMix. The statistically significantly increased levels of NO (p<\/span> = 0.002, p<\/span> = 0.004) suggest that the cells are trying to adapt to the environment that they have been exposed to. Conclusions:<\/b> Within the limitations of the present study, under the tested conditions, our results suggest that Ketac\u2122 Molar EasyMix maintained cell viability close to the 70% threshold defined by ISO 10993-5:2009, indicating a borderline biological response, a feature that may be influenced by the composition and behavior of the material.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Keywords: <\/strong><\/p>

root perforation<\/a>; <\/a>biocompatibility<\/a>; <\/a>FT-IR<\/a>; <\/a>glass ionomer<\/a>; <\/a>XRD<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tRead the paper online<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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