{"id":3085,"date":"2026-04-01T12:00:00","date_gmt":"2026-04-01T12:00:00","guid":{"rendered":"https:\/\/cicds.umfcd.ro\/?post_type=lucrari_cercetari&p=3085"},"modified":"2026-08-05T15:44:49","modified_gmt":"2026-08-05T15:44:49","slug":"study-on-the-influence-of-hydroxyapatite-on-human-cell-viability-and-adhesion-in-chemical-antibacterial-silver-coatings","status":"publish","type":"lucrari_cercetari","link":"https:\/\/cicds.umfcd.ro\/en\/lucrari_cercetari\/study-on-the-influence-of-hydroxyapatite-on-human-cell-viability-and-adhesion-in-chemical-antibacterial-silver-coatings\/","title":{"rendered":"Study on the Influence of Hydroxyapatite on Human Cell Viability and Adhesion in Chemical Antibacterial Silver Coatings"},"content":{"rendered":"
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Study on the Influence of Hydroxyapatite on Human Cell Viability and Adhesion in Chemical Antibacterial Silver Coatings<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Vasilescu, V.-G.; Cucuruz, A.; Ciocan, L.T.; Stan, M.S.; Miculescu, F.; Voinea, I.C.; Cotru\u021b, C.M.; Dediu-Botezatu, A.V.; Vasilescu, E.; \u021a\u00e2ncu, A.M.; Imre, M.; Pi\u021buru, S.M.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dentistry Journal 2026, 14, 202.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Objectives: In dental implantology, the priorities in scientific research are to identify solutions that guarantee a beneficial biomaterial\u2013tissue interaction, both in terms of implant biointegration and protection against infections. The experimental approach consisted of chemical deposition of silver (Ag), silver and hydroxyapatite (HAP) on a TiZr metallic support. The aim of the research is to study the influence of hydroxyapatite on the possible adverse effects produced by silver in antibacterial coatings. Methods: The characterization of the coating was performed by scanning electron microscopy (SEM) and EDS spectroscopy, XRD diffraction and FT-IR infrared analysis. In vitro cell viability and adhesion testing was performed by quantitative (MTT) and qualitative fluorescence-based assays on samples (without deposition and with chemical deposition), in the presence of human fetal osteoblasts (hFOB cell line) after 8 days of incubation. Results: The findings of the study indicate an increase in cell viability by combining silver with hydroxyapatite. Preliminary data indicated a cell viability of 20% when the metal support is coated exclusively with silver and 60% in the presence of hydroxyapatite in the silver coating. Conclusions: The experimental study offers insights into the potential cytotoxic effects of silver in antibacterial coatings. Co-deposition with hydroxyapatite improved osteoblast viability compared to surfaces coated with silver alone, indicating that it may have a beneficial effect in Ag-based surface functionalization. The underlying mechanism (e.g., modulation of silver species\/ion release) was not directly quantified in this work and should be addressed in future studies.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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TiZr bioalloy; silver (Ag); antibacterial effect; cytotoxicity; hydroxyapatite (HAp); biocompatibility; cell viability; human osteoblasts<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tRead the paper online<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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