{"id":2321,"date":"2024-05-20T13:29:00","date_gmt":"2024-05-20T13:29:00","guid":{"rendered":"https:\/\/cicds.umfcd.ro\/?post_type=lucrari_cercetari&p=2321"},"modified":"2024-10-01T13:32:24","modified_gmt":"2024-10-01T13:32:24","slug":"development-of-biologically-active-phytosynthesized-silver-nanoparticles-using-marrubium-vulgare-l-extracts-applications-and-cytotoxicity-studies","status":"publish","type":"lucrari_cercetari","link":"https:\/\/cicds.umfcd.ro\/en\/lucrari_cercetari\/development-of-biologically-active-phytosynthesized-silver-nanoparticles-using-marrubium-vulgare-l-extracts-applications-and-cytotoxicity-studies\/","title":{"rendered":"Development of Biologically Active Phytosynthesized Silver Nanoparticles Using\u00a0Marrubium vulgare\u00a0L. Extracts: Applications and Cytotoxicity Studies"},"content":{"rendered":"
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Development of Biologically Active Phytosynthesized Silver Nanoparticles Using\u00a0Marrubium vulgare\u00a0L. Extracts: Applications and Cytotoxicity Studies<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Lupuliasa AI, Prisada RM, Matei Brazdis RI, Avramescu SM, Vasile B\u0218, Fierascu RC, Fierascu I, Voicu-B\u0103la\u0219ea B, Mele\u0219canu Imre M, Pi\u021buru SM, Anu\u021ba V, Dinu-P\u00eervu CE<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Nanomaterials<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\tAbstract\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Metal nanoparticle phytosynthesis has become, in recent decades, one of the most promising alternatives for the development of nanomaterials using \u201cgreen chemistry\u201d methods. The present work describes, for the first time in the literature, the phytosynthesis of silver nanoparticles (AgNPs) using extracts obtained by two methods using the aerial parts of\u00a0Marrubium vulgare<\/span>\u00a0L. The extracts (obtained by classical temperature extraction and microwave-assisted extraction) were characterized in terms of total phenolics content and by HPLC analysis, while the phytosynthesis process was confirmed using X-ray diffraction and transmission electron microscopy, the results suggesting that the classical method led to the obtaining of smaller-dimension AgNPs (average diameter under 15 nm by TEM). In terms of biological properties, the study confirmed that AgNPs as well as the\u00a0M. vulgare<\/span>\u00a0crude extracts reduced the viability of human gingival fibroblasts in a concentration- and time-dependent manner, with microwave-assisted extracts having the more pronounced effects. Additionally, the study unveiled that AgNPs transiently increased nitric oxide levels which then decreased over time, thus offering valuable insights into their potential therapeutic use and safety profile.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Keywords: phytosynthesis; Marrubium vulgare L.; silver nanoparticles; extract characterization;
biomedical applications<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDownload paper\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/span>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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