{"id":1282,"date":"2024-06-01T12:34:16","date_gmt":"2024-06-01T12:34:16","guid":{"rendered":"https:\/\/umfcd.inobox.ro\/?post_type=lucrari_cercetari&p=1282"},"modified":"2024-09-26T13:12:15","modified_gmt":"2024-09-26T13:12:15","slug":"pi3k-akt-mtor-signaling-pathway-a-key-player-in-the-molecular-landscape-of-malignant-transformation-of-oral-lesions","status":"publish","type":"lucrari_cercetari","link":"https:\/\/cicds.umfcd.ro\/en\/lucrari_cercetari\/pi3k-akt-mtor-signaling-pathway-a-key-player-in-the-molecular-landscape-of-malignant-transformation-of-oral-lesions\/","title":{"rendered":"Pi3k\/akt\/mtor signaling pathway \u2013 a key player in the molecular landscape of malignant transformation of oral lesions"},"content":{"rendered":"
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t

Pi3k\/akt\/mtor signaling pathway \u2013 a key player in the molecular landscape of malignant transformation of oral lesions<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\tMihai Radu Moisa1,<\/sup> , Elena Claudia Coculescu1<\/sup> , Marina Imre1<\/sup> , Alexandra Ripszky1<\/sup> , Bogdan-Ioan Coculescu2,3*<\/sup> , Silviu Mirel Pi\u021buru1<\/sup>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

\u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest, Romania 1Faculty of Stomatology,
\n2<\/sup> Faculty of Midwifery and Nursing.
\n3<\/sup> \u201cCantacuzino\u201d National Medico-Military Institute for Research and Development, Bucharest, Romania.
\n*<\/sup>Corresponding author: Bogdan-Ioan Coculescu; email: bogdancoculescu@yahoo.fr <\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\tAbstract\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Aberrant PI3K\/AKT\/mTOR\/ pathway have been considered one of the starting points of various types of human cancer, including the oral squamous cell carcinoma (OSCC). The important role played by this signaling pathway in oncogenesis and cancer evolution, oriented the researchers\u2019 attention toward studies of AKT and the PI3K\/AKT\/mTOR axis in the context of malignant transformation of oral precancerous lesions. Consequently, this article\u2019s aim is an update of the possible key role played by the PI3K \/AKT\/mTOR axis on the oral lesions\u2019
malignant transformation stage.\u00a0
Oral potentially malignant disorders are defined as lesions that will most probably progress to malignant lesions of the oral cavity. These lesions are mainly represented by leukoplakia, erythroplakia, actinic cheilitis and lichen planus.
PI3K\/AKT\/mTOR signaling cascade should be regarded as a crucial subject for additional research, focusing not only on the early identification of malignant transformations of oral lesions, but also on opening new therapeutic ways in order to prevent malignant transformation and OSCC evolution.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t

Key words: PI3K\/AKT\/mTOR pathway, leukoplakia, erythroplakia, lichen planus, oral potentially malignant disorders<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tRead the paper online<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n\n\t\t\t\t\t\t
\n\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t
\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDownload paper\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/span>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"featured_media":0,"menu_order":0,"template":"","meta":{"_acf_changed":false},"lucrari_cercetari_cat":[],"class_list":["post-1282","lucrari_cercetari","type-lucrari_cercetari","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cicds.umfcd.ro\/en\/wp-json\/wp\/v2\/lucrari_cercetari\/1282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cicds.umfcd.ro\/en\/wp-json\/wp\/v2\/lucrari_cercetari"}],"about":[{"href":"https:\/\/cicds.umfcd.ro\/en\/wp-json\/wp\/v2\/types\/lucrari_cercetari"}],"version-history":[{"count":13,"href":"https:\/\/cicds.umfcd.ro\/en\/wp-json\/wp\/v2\/lucrari_cercetari\/1282\/revisions"}],"predecessor-version":[{"id":2216,"href":"https:\/\/cicds.umfcd.ro\/en\/wp-json\/wp\/v2\/lucrari_cercetari\/1282\/revisions\/2216"}],"wp:attachment":[{"href":"https:\/\/cicds.umfcd.ro\/en\/wp-json\/wp\/v2\/media?parent=1282"}],"wp:term":[{"taxonomy":"lucrari_cercetari_cat","embeddable":true,"href":"https:\/\/cicds.umfcd.ro\/en\/wp-json\/wp\/v2\/lucrari_cercetari_cat?post=1282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}